Is aging just Inflammation noise in the Epigenetic system reading our DNA code?
The aging question
Why do we age, age at different rates, but with the same pattern of decline? We find plausible answers in a new book, Lifespan by David Sinclair. Sinclair uses scientific research to prove inflammation contributes to aging.
Lifespan by David Sinclair says, “It’s the inflammation”
Lifespan: Why We Age―and Why We Don’t Have To, is based on research by author and Harvard Biologist, David A. Sinclair, Ph.D.
Sinclair addresses these questions by explaining and testing the Inflammation Theory. The Inflammation Theory says environmental exposures mess with the expression of our DNA. Inflammation scrambles how our body reads the genetic code.
Epigenetic reader of DNA Code
Boomers saw the discovery of DNA as the genetic code underlying heredity. DNS is the famous double helix of deoxyribonucleic acid. DNA’s discovery won the Nobel Prize in Science. In school, we learned about DNA and messenger RNA. But science has gone much deeper over the last thirty years.
Every code requires a reader or decoder. We now know that the expression of DNA traits depends on environmental exposures. Those exposures force the body to request the right answer from the DNA program. Epigenetics is this environmental or expression aspect of genetics. Epigenetics explains when the body reads and expresses the digital code of DNA.
DNA is digital, but Epigenetics involves the analog amplitude of the environmental signal. How loud is the request for information and the response from the digitally encoded DNA? Rather than only 0, 1, (or on-off), DNA encodes four options.
After 25 years of researching aging & having read thousands of scientific papers, if there’s one simple piece of advice to stay healthy longer & max. your lifespan it’s this: eat less often. The cool new stuff is in my book. Excited it’s shipping. Get one.https://t.co/HHyEWdQblg
— Lifespan by David Sinclair, PhD AO (@davidasinclair) September 8, 2019
Too much noise or inflammation means DNA read errors
In practical terms? Ever listen to a scratched Compact Disc (CD) in your CD player? And you hear the music miss a beat, get stuck, or skip? The music suffers. However, the digital code is still there under the scratch, but the CD player can’t read it correctly. Like a digital compact disc read error, the body’s errors in DNA reading leads to problems – aging. Inflammation is the noise or static in the body’s system. And, this analogy by Sinclair is easy for Boomers to understand.
Different environmental exposures, different rates of aging
So why do we age at different rates? According to Lifespan by David Sinclair? Some of us have more environmental exposures and more resulting inflammation noise.
Evidence we may be able to slow or even reverse aging
The good news? There’s evidence that we can slow down the accumulated epigenetic noise. Or even reverse aging to a degree. How? Improve the epigenetic reading of the underlying DNA code. Less static reduces the frequency and severity of errors. The first step? Reduce chronic inflammation, a key source of noise in the reading system. Inflammation can overwhelm the request or the answer. Another step? Increase the volume or strength of the request. Shouting for instructions breaks through the noise of inflammation.
What works to encourage longevity today
In practical terms? This explains why intermittent fasting encourages longevity. Eating less often seems to both reduce inflammation and send a stronger read signal. Thus, epigenetics explains the increasing evidence that too much sugar causes health problems. And high-intensity interval training (HIIT) has more anti-aging effects than other exercise types. And Lifespan suggests more progress towards healthy aging is possible. Fight inflammation and help our body clearly read our DNA.
Lifespan by David Sinclair is on our next book to read list for the Aging With Freedom Book Club. More to come after a full read.